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There are no large randomized controlled trials or conclusive summaries of the existing literature. Three analgin tablete doziranje Cochrane reviews on the effectiveness and safety of metamizole for acute postoperative pain 8, acute renal colic pain 9, and acute primary headaches 19 concluded that metamizole offers good short-term pain relief.In the conventional synthesis route for the analgin, 4-aminoantipyrine AA is prepared into the analgin through four reactions, namely formylation, methylation, hydrolysis and condensation, while in the new method, the 4-aminoantipyrine AA paraformaldehyde and sodium hydrosulfite are directly subjected to condensation to form 4-N-demethylanalgin, and the 4-N-demethylanalgin and dimethyl sulfate are subjected to methylation under weak alkaline condition to form the analgin.
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