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We investigated the combined effects of minoxidil and retinol on human hair growth in vitro and on cultured human dermal papilla cells DPCs and epidermal keratinocytes HaCaT The combination of minoxidil and retinol additively promoted hair growth in hair follicle organ cultures. In addition, minoxidil plus retinol more effectively elevated phosphorylated Erk, phosphorylated Akt levels, and the Bcl-2/Bax ratio than minoxidil alone in DPCs and HaCaT.I have had some panic moments with tretinoin cream where my skin was so dehydrated I looked like death clear skin though But I would slap on vaseline at night and some nights mix Magnesium ascorbyl phosphate powder with it and just massage the heck out of it and my skin was magnificent.

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