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Naltrexone
Clinical data
Trade namesReVia, Vivitrol, others
AHFS/Drugs.comMonograph
MedlinePlusa685041
Pregnancy categoryAU: B3 US: C (Risk not ruled out)
Routes of administrationBy mouth, intramuscular injection, subcutaneous implant
ATC codeN07BB04 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability5–40%
Protein binding21%
MetabolismLiver
Elimination half-lifeNaltrexone: 4 hours 6β-Naltrexol: 13 hours
ExcretionUrine

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Warn patients of the risk of hepatic injury; advise them to seek help if experiencing symptoms of acute hepatitis. Discontinue use of VIVITROL in patients who exhibit acute hepatitis symptoms.And while birth defects have not been seen in animals, miscarriage has occurred in rats and rabbits treated with very high doses of naltrexone.

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38 FR 8254, Mar. Redesignated at 38 FR 26609, Sept.Naltrexone is one how does naltrexone reduce cravings of a comprehensive treatment plan, which includes counseling and other behavioral health therapies to provide patients with a whole-person approach.

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