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Cerner Multum, nc.In one aspect, the present invention provides a solution formulation for tiotropium bromide structure from a nebuliser comprising tiotropium, water, sodium chloride, and an acid selected from HCI, citric acid, or a mixture thereof; wherein the formulation is substantially free of preservatives and further stabilisers.

Examples of preservatives which are not present are benzalkonium chloride, benzoic acid or benzoates such as sodium benzoate.

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COPD. 2013 Aug; 4 511-22.It is sparingly soluble in water and soluble in methanol. The structural formula is: Tiotropium bromide monohydrate has a molecular mass of 490.

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